GUIDE
Does NAD+ therapy work, and is it safe?
NAD+ is a coenzyme your cells need to produce energy and carry out repair, and several human tissues show lower NAD+ with age. Supplements and infusions can raise NAD+ levels, and short-term use appears generally well tolerated. Rigorous evidence that raising NAD+ improves health outcomes in people is still limited. At LongevityNow it is used selectively, physician-supervised, and only when your assessment supports it.
What NAD+ actually is
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell. It is central to how cells turn food into energy and is a required substrate for repair enzymes, including the sirtuins and PARPs that maintain DNA and regulate metabolism (Nature Reviews Molecular Cell Biology, 2021). It is fundamental cell biology, not a supplement invented for marketing.
Does NAD+ decline with age?
In several human tissues, including skin, brain, and skeletal muscle, NAD+ has been shown to fall with age. The picture in blood is less consistent, and researchers note that overall human data are still limited and vary by tissue (Nature Reviews Molecular Cell Biology, 2021). So the honest summary is: a decline is well documented in some tissues, not uniformly proven everywhere.
Can you raise NAD+, and does that help?
Yes, you can raise it. In a randomised trial, six weeks of the precursor nicotinamide riboside raised NAD+ in blood cells by about 60 percent and was well tolerated, but it did not prove clinical health benefits; only preliminary trends were seen (Nature Communications, 2018). Raising a marker is not the same as improving health, and adequately powered trials confirming benefit are still lacking (systematic review, 2026).
Is intravenous NAD+ safe?
Short-term tolerability in the studies to date has generally been favourable, but long-term outcome data are limited. As with any intravenous therapy, suitability depends on your individual health history, which is why every protocol is individually screened and physician-supervised. It is not appropriate for everyone.
How LongevityNow uses NAD+
We use NAD+ selectively, as a dosed and supervised protocol, and only when your assessment supports it. It is never offered as a default or framed as a cure. We describe what the evidence does, and does not, support, and choose it from your data rather than from a package.
| Common claim | What the evidence shows |
|---|---|
| NAD+ therapy reverses aging | Not established in humans; no adequately powered trials show this |
| NAD+ falls with age | Shown in several human tissues; the picture in blood is mixed |
| Supplements can raise NAD+ | Yes, precursors reliably raise blood NAD+ in trials |
| It improves energy and healthspan | Plausible mechanism, but clinical benefit is not yet proven |
| It is safe | Short-term use generally well tolerated; long-term data limited; screening required |
Frequently asked questions
Does NAD+ therapy reverse aging?
No. That is not established in humans. NAD+ can be raised, but adequately powered trials showing it reverses aging do not exist. We describe what the evidence does, and does not, support.
Is NAD+ infusion safe?
Short-term use is generally well tolerated in the studies to date, but long-term data are limited. Suitability depends on your health history, so every protocol is individually screened and physician-supervised.
What is the difference between IV NAD+ and oral precursors?
Oral precursors such as nicotinamide riboside reliably raise blood NAD+ and are convenient. Intravenous NAD+ delivers it directly. The evidence for clinical benefit is limited for both, so which, if either, is appropriate depends on your assessment.
How many sessions are involved?
It is a dosed protocol, typically several sessions across several weeks, used selectively based on what your assessment shows rather than on a fixed package.
Who should not have NAD+ therapy?
As with any intravenous therapy, some health conditions make it unsuitable. That is determined during screening before any protocol begins, and we will tell you directly if it is not right for you.
References
- Covarrubias AJ, et al. NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology. 2021. View source →
- Martens CR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications. 2018. View source →
- NAD+ supplementation for anti-aging and wellness: a PRISMA-guided systematic review of preclinical and clinical evidence. 2026. View source →
This guide is general information, reviewed by our clinical team, and is not a substitute for individual medical advice.
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